The October Journal club and dispatched not one but two papers:
Caterino JM, Hains DS, Camargo CA, Quraishi SA, Saxena V, Schwaderer AL. A
Prospective, Observational Pilot Study of the Use of Urinary Antimicrobial
Peptides in Diagnosing Emergency Department Patients With Positive Urine
Cultures. Acad Emerg Med. 2015 Oct;22(10):1226-30. doi: 10.1111/acem.12770. Full text freely available
Keh D, Trips E, Marx G, Wirtz SP, Abduljawwad E, Bercker S, Bogatsch H,
Briegel J, Engel C, Gerlach H, Goldmann A, Kuhn SO, Hüter L, Meier-Hellmann A,
Nierhaus A, Kluge S, Lehmke J, Loeffler M, Oppert M, Resener K, Schädler D,
Schuerholz T, Simon P, Weiler N, Weyland A, Reinhart K, Brunkhorst FM;
SepNet–Critical Care Trials Group.. Effect of Hydrocortisone on Development of
Shock Among Patients With Severe Sepsis: The HYPRESS Randomized Clinical Trial.
JAMA. 2016 Oct 3. doi: 10.1001/jama.2016.14799. Full text freely available
The first paper we found methodologically lacking. The HYPRESS paper was of a much higher standard, but its conclusions were that hydrocortisone did not prevent the development of shock in severe sepsis.